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Article

HER2 over-expressing high grade endometrial cancer expresses high levels of p95HER2 variant.

Gynecologic oncology - 1 Apr 2015

Growdon Whitfield B, Groeneweg Jolijn, Byron Virginia, DiGloria Celeste, Borger Darrell R, Tambouret Rosemary, Foster Rosemary, Chenna Ahmed, Sperinde Jeff, Winslow John, Rueda Bo R

Abstract excerpt

BACKGROUND: Subsets of high grade endometrial cancer (EnCa) over-express HER2 (ERBB2), yet clinical trials have failed to demonstrate any anti-tumor activity utilizing trastuzumab, an approved platform for HER2 positive breast cancer (BrCa). A truncated p95HER2 variant lacking the trastuzumab binding site may confer resistance. The objective of this investigation was to characterize the expression of the p95HER2...

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Share to Carcinoma, Endometrioid
Share to Endometrial Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Amplification

Share to In Situ Hybridization, Fluorescence

Share to Neoplasm Grading

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Share to Receptor, ErbB-2

Source

Open in PubMed Open full text

Identifiers

PMID: 25602714
DOI: 10.1016/j.ygyno.2015.01.533
PMCID: PMC4380649

Genes

ERBB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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