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Article

FGFR2 mutations promote endometrial cancer progression through dual engagement of EGFR and Notch signalling pathways.

Clinical and translational medicine - 1 May 2023

Dixit Garima, Gonzalez-Bosquet Jesus, Skurski Joseph, Devor Eric J, Dickerson Erin B, Nothnick Warren B, Issuree Priya D, Leslie Kimberly K, Maretzky Thorsten

Abstract excerpt

BACKGROUND: Mutations in the receptor tyrosine kinase gene fibroblast growth factor receptor 2 (FGFR2) occur at a high frequency in endometrial cancer (EC) and have been linked to advanced and recurrent disease. However, little is known about how these mutations drive carcinogenesis. METHODS: Differential transcriptomic analysis and two-step quantitative real-time PCR (qRT-PCR) assays were applied to identify...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37165578
DOI: 10.1002/ctm2.1223
PMCID: PMC10172618

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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