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Article

Dissociation of blood-brain barrier disruption and disease manifestation in an aquaporin-4-deficient mouse model of amyotrophic lateral sclerosis.

Neuroscience research - 1 Aug 2018

Watanabe-Matsumoto Saori, Moriwaki Yasuhiro, Okuda Takashi, Ohara Shinji, Yamanaka Koji, Abe Yoichiro, Yasui Masato, Misawa Hidemi

Abstract excerpt

Aquaporin-4 (AQP4) is abundantly expressed in the central nervous system and is involved in the water balance in the cellular environment. Previous studies have reported that AQP4 expression is upregulated in rat models of amyotrophic lateral sclerosis (ALS), a fatal disease that affects motor neurons in the brain and spinal cord. In this study, we report that astrocytic AQP4 overexpression is evident during the...

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Source

Identifiers

PMID: 29154923
DOI: 10.1016/j.neures.2017.11.001

Genes

AQP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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