Article
EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans.
Nature medicine - 1 Sept 2012
Van Hoecke Annelies, Schoonaert Lies, Lemmens Robin, Timmers Mieke, Staats Kim A, Laird Angela S, Peeters Elke, Philips Thomas, Goris An, Dubois Bénédicte, Andersen Peter M, Al-Chalabi Ammar, Thijs Vincent, Turnley Ann M, van Vught Paul W, Veldink Jan H, Hardiman Orla, Van Den Bosch Ludo, Gonzalez-Perez Paloma, Van Damme Philip, Brown Robert H, van den Berg Leonard H, Robberecht Wim
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting motor neurons. Disease onset and progression are variable, with survival ranging from months to decades. Factors underlying this variability may represent targets for therapeutic intervention. Here, we have screened a zebrafish model of ALS and identified Epha4, a receptor in the ephrin axonal repellent system, as a modifier of the...
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