Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cloning and chromosomal localization of mouse aquaporin 4: exclusion of a candidate mutant phenotype, ataxia.

Genomics - 15 Apr 1997

Turtzo L C, Lee M D, Lu M, Smith B L, Copeland N G, Gilbert D J, Jenkins N A, Agre P

Abstract excerpt

Aquaporin-4 is a mammalian water channel protein that is predominately expressed in brain, where it is believed to mediate water homeostasis. Here we report the isolation and characterization of the cDNA for mouse Aqp4 and map the gene to the proximal region of mouse chromosome 18. This region contains the neurological mutation ataxia, but further analysis reveals that Aqp4 is not responsible for the ataxia...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to Chromosome Mapping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cloning, Molecular

Share to Molecular Sequence Data

Share to Mutation

Share to Phenotype

Source

Identifiers

PMID: 9143504
DOI: 10.1006/geno.1997.4641

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Cloning and chromosomal localization of mouse aquaporin 4: exclusion of a candidate mutant phenotype, ataxia.PMID 9143504Read ↗

A mutation in Af4 is predicted to cause cerebellar ataxia and cataracts in the robotic mouse.Semantic proximity Read ↗

Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4.Semantic proximity Read ↗

The Na,K-ATPase alpha4 gene (Atp1a4) encodes a ouabain-resistant alpha subunit and is tightly linked to the alpha2 gene (Atp1a2) on mouse chromosome 1.Semantic proximity Read ↗

Dissociation of blood-brain barrier disruption and disease manifestation in an aquaporin-4-deficient mouse model of amyotrophic lateral sclerosis.Semantic proximity Read ↗

New insights into water transport and edema in the central nervous system from phenotype analysis of aquaporin-4 null mice.Semantic proximity Read ↗

Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice.Semantic proximity Read ↗

Compensation for a gene trap mutation in the murine microtubule-associated protein 4 locus by alternative polyadenylation and alternative splicing.Semantic proximity Read ↗

Mouse aquaporin 10 gene (AQP10) is a pseudogene.Semantic proximity Read ↗

Claudin 4 knockout mice: normal physiological phenotype with increased susceptibility to lung injury.Semantic proximity Read ↗

Molecular Cloning and Chromosomal Assignment of the Mouse C-Type Natriuretic Peptide (CNP) Gene (Nppc): Comparison with the Human CNP Gene (NPPC)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.