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Article

Pathway-specific alteration of synaptic plasticity in Tg2576 mice.

Molecules and cells - 1 Aug 2011

Jung Jung Hoon, An Kyongman, Kwon Oh Bin, Kim Hye-sun, Kim Joung-Hun

Abstract excerpt

Various animal models of Alzheimer disease (AD) are characterized by deficits in spatial memory that are causally related to altered synaptic function and impairment of long-term potentiation (LTP) in the hippocampus. In Tg2576 AD mice, we compared LTP in 2 major hippocampal pathways, Schaffer collateral (SC) and mossy fiber (MF) pathways. Whereas LTP was completely abolished in the SC pathway of Tg2576 mice, we...

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Source

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Identifiers

PMID: 21638202
DOI: 10.1007/s10059-011-0077-8
PMCID: PMC3887667

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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