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Article

Variations of the angiotensin II type 1 receptor gene are associated with extreme human longevity.

Age (Dordrecht, Netherlands) - 1 Jun 2013

Benigni Ariela, Orisio Silvia, Noris Marina, Iatropoulos Paraskevas, Castaldi Davide, Kamide Kei, Rakugi Hiromi, Arai Yasumichi, Todeschini Marta, Ogliari Giulia, Imai Enyu, Gondo Yasuyuki, Hirose Nobuyoshi, Mari Daniela, Remuzzi Giuseppe

Abstract excerpt

Longevity phenotype in humans results from the influence of environmental and genetic factors. Few gene polymorphisms have been identified so far with a modest effect on lifespan leaving room for the search of other players in the longevity game. It has been recently demonstrated that targeted disruption of the mouse homolog of the human angiotensin II type 1 receptor (AT1R) gene (AGTR1) translates into marked...

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Identifiers

PMID: 22569962
DOI: 10.1007/s11357-012-9408-8
PMCID: PMC3636412

Genes

AGTR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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