Article

Silmitasertib, an FDA-designated orphan CK2 Inhibitor, ameliorates neuropathology and motor dysfunction in a Huntington’s disease mouse model

2025-11-20

Abstract excerpt

Huntington’s disease (HD) is a devastating autosomal dominant neurodegenerative disease that manifests with progressive motor, cognitive, and psychological impairments. HD is caused by a polyQ (CAG) repeat expansion in the huntingtin ( HTT ) gene, leading to the misfolding and aggregation of mutant HTT protein (mHTT) and the preferential degeneration of the striatum. Previously in our lab, we identified Protein K...

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Literature Corpus work: 0188b5fa-24cd-50ea-a661-6979e2ef8f01
DOI: 10.1101/2025.11.19.689275

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