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Article

Janus kinase deregulation in leukemia and lymphoma.

Immunity - 20 Apr 2012

Chen Edwin, Staudt Louis M, Green Anthony R

Abstract excerpt

Genetic alterations affecting members of the Janus kinase (JAK) family have been discovered in a wide array of cancers and are particularly prominent in hematological malignancies. In this review, we focus on the role of such lesions in both myeloid and lymphoid tumors. Oncogenic JAK molecules can activate a myriad of canonical downstream signaling pathways as well as directly interact with chromatin in...

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Source

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Identifiers

PMID: 22520846
DOI: 10.1016/j.immuni.2012.03.017
PMCID: PMC7480953

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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