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Article

Current outlook on molecular pathogenesis and treatment of myeloproliferative neoplasms.

Molecular diagnosis & therapy - 1 Oct 2012

Tibes Raoul, Bogenberger James M, Benson Kasey L, Mesa Ruben A

Abstract excerpt

Discovery of the JAK2 V617F mutation in the myeloproliferative neoplasms (MPNs) essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF) has stimulated great interest in the underlying molecular mechanisms and treatment of these diseases. Along with acceleration of technologies, novel mutations in genes such as MPL, LNK, and CBL have been discovered that converge on the JAK-STAT...

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Source

Identifiers

PMID: 23023734
DOI: 10.1007/s40291-012-0006-3

Genes

JAK2
ASXL1
CBL
IDH1
MPL
TET2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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