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Article

Dual activation of CFTR and CLCN2 by lubiprostone in murine nasal epithelia.

American journal of physiology. Lung cellular and molecular physiology - 1 Mar 2013

Schiffhauer Eric S, Vij Neeraj, Kovbasnjuk Olga, Kang Po Wei, Walker Doug, Lee Seakwoo, Zeitlin Pamela L

Abstract excerpt

Multiple sodium and chloride channels on the apical surface of nasal epithelial cells contribute to periciliary fluid homeostasis, a function that is disrupted in patients with cystic fibrosis (CF). Among these channels is the chloride channel CLCN2, which has been studied as a potential alternative chloride efflux pathway in the absence of CFTR. The object of the present study was to use the nasal potential...

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Share to Chloride Channels
Share to Cystic Fibrosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cystic Fibrosis Transmembrane Conductance Regulator

Share to Ion Transport

Share to Membrane Potentials

Share to Mice, Transgenic

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Source

Open in PubMed Open full text

Identifiers

PMID: 23316067
DOI: 10.1152/ajplung.00277.2012
PMCID: PMC3602739

Genes

CLCN2
CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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