Article
An exome sequencing based approach for genome-wide association studies in the dog.
Scientific reports - 15 Nov 2017
Broeckx Bart J G, Derrien Thomas, Mottier Stéphanie, Wucher Valentin, Cadieu Edouard, Hédan Benoît, Le Béguec Céline, Botherel Nadine, Lindblad-Toh Kerstin, Saunders Jimmy H, Deforce Dieter, André Catherine, Peelman Luc, Hitte Christophe
Abstract excerpt
Genome-wide association studies (GWAS) are widely used to identify loci associated with phenotypic traits in the domestic dog that has emerged as a model for Mendelian and complex traits. However, a disadvantage of GWAS is that it always requires subsequent fine-mapping or sequencing to pinpoint causal mutations. Here, we performed whole exome sequencing (WES) and canine high-density (cHD) SNP genotyping of 28...
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