Article
Complex disease and phenotype mapping in the domestic dog.
Nature communications - 22 Jan 2016
Hayward Jessica J, Castelhano Marta G, Oliveira Kyle C, Corey Elizabeth, Balkman Cheryl, Baxter Tara L, Casal Margret L, Center Sharon A, Fang Meiying, Garrison Susan J, Kalla Sara E, Korniliev Pavel, Kotlikoff Michael I, Moise N S, Shannon Laura M, Simpson Kenneth W, Sutter Nathan B, Todhunter Rory J, Boyko Adam R
Abstract excerpt
The domestic dog is becoming an increasingly valuable model species in medical genetics, showing particular promise to advance our understanding of cancer and orthopaedic disease. Here we undertake the largest canine genome-wide association study to date, with a panel of over 4,200 dogs genotyped at 180,000 markers, to accelerate mapping efforts. For complex diseases, we identify loci significantly associated...
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