Article
A simple genetic architecture underlies morphological variation in dogs.
PLoS biology - 10 Aug 2010
Boyko Adam R, Quignon Pascale, Li Lin, Schoenebeck Jeffrey J, Degenhardt Jeremiah D, Lohmueller Kirk E, Zhao Keyan, Brisbin Abra, Parker Heidi G, vonHoldt Bridgett M, Cargill Michele, Auton Adam, Reynolds Andy, Elkahloun Abdel G, Castelhano Marta, Mosher Dana S, Sutter Nathan B, Johnson Gary S, Novembre John, Hubisz Melissa J, Siepel Adam, Wayne Robert K, Bustamante Carlos D, Ostrander Elaine A
Abstract excerpt
Domestic dogs exhibit tremendous phenotypic diversity, including a greater variation in body size than any other terrestrial mammal. Here, we generate a high density map of canine genetic variation by genotyping 915 dogs from 80 domestic dog breeds, 83 wild canids, and 10 outbred African shelter dogs across 60,968 single-nucleotide polymorphisms (SNPs). Coupling this genomic resource with external measurements...
Topics
- Animals
- Animals, Domestic
- Body Size
- Dogs
- Genetic Variation
- Genome
- Genome-Wide Association Study
- Phenotype
- Polymorphism, Single Nucleotide