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Article

Structural insights into RNA-dependent eukaryal and archaeal selenocysteine formation.

Nucleic acids research - 1 Mar 2008

Araiso Yuhei, Palioura Sotiria, Ishitani Ryuichiro, Sherrer R Lynn, O'Donoghue Patrick, Yuan Jing, Oshikane Hiroyuki, Domae Naoshi, Defranco Julian, Söll Dieter, Nureki Osamu

Abstract excerpt

The micronutrient selenium is present in proteins as selenocysteine (Sec). In eukaryotes and archaea, Sec is formed in a tRNA-dependent conversion of O-phosphoserine (Sep) by O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase (SepSecS). Here, we present the crystal structure of Methanococcus maripaludis SepSecS complexed with PLP at 2.5 A resolution. SepSecS, a member of the Fold Type I PLP enzyme family, forms an...

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PMID: 18158303
DOI: 10.1093/nar/gkm1122
PMCID: PMC2275076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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