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Article

An unbiased in vitro screen for activating epidermal growth factor receptor mutations

6 Apr 2019

Abstract excerpt

Cancer tissues harbor thousands of mutations, and a given oncogene may be mutated at hundreds of sites, yet only a few of these mutations have been functionally tested. Here, we describe an unbiased platform for the functional characterization of thousands of variants of a single receptor tyrosine kinase (RTK) gene in a single assay. Our in vitro screen for activating mutations (iSCREAM) platform enabled rapid...

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PMID: 30952700
DOI: 10.1074/jbc.ra118.006336

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