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Article

Rare mutation-dominant compound EGFR-positive NSCLC is associated with enriched kinase domain-resided variants of uncertain significance and poor clinical outcomes.

BMC medicine - 24 Feb 2023

Zhao Weixin, Song Ailing, Xu Yang, Wu Qian, Liu Cuicui, Yin Jiani C, Ou Qiuxiang, Wu Xue, Shao Yang, Zhao Xinmin

Abstract excerpt

BACKGROUND: Compound epidermal growth factor receptor (EGFR) mutations are less responsive to tyrosine kinase inhibitors (TKIs) than single EGFR mutations in non-small cell lung cancer (NSCLC). However, the detailed clinical characteristics and prognosis of various compound EGFR mutations remain to be elucidated. METHODS: We retrospectively studied the next-generation sequencing (NGS) data of treatment-naïve...

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Identifiers

PMID: 36829178
DOI: 10.1186/s12916-023-02768-z
PMCID: PMC9960474

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