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Article

Human stem cell-derived astrocytes replicate human prions in a PRNP genotype-dependent manner.

The Journal of experimental medicine - 4 Dec 2017

Krejciova Zuzana, Alibhai James, Zhao Chen, Krencik Robert, Rzechorzek Nina M, Ullian Erik M, Manson Jean, Ironside James W, Head Mark W, Chandran Siddharthan

Abstract excerpt

Prions are infectious agents that cause neurodegenerative diseases such as Creutzfeldt-Jakob disease (CJD). The absence of a human cell culture model that replicates human prions has hampered prion disease research for decades. In this paper, we show that astrocytes derived from human induced pluripotent stem cells (iPSCs) support the replication of prions from brain samples of CJD patients. For experimental...

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Source

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Identifiers

PMID: 29141869
DOI: 10.1084/jem.20161547
PMCID: PMC5716027

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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