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Article

Biochemical and strain properties of CJD prions: complexity versus simplicity.

Journal of neurochemistry - 1 Oct 2011

Haïk Stéphane, Brandel Jean-Philippe

Abstract excerpt

Prions, the agents responsible for transmissible spongiform encephalopathies, are infectious proteins consisting primarily of scrapie prion protein (PrP(Sc)), a misfolded, β-sheet enriched and aggregated form of the host-encoded cellular prion protein (PrP(C)). Their propagation is based on an autocatalytic PrP conversion process. Despite the lack of a nucleic acid genome, different prion strains have been...

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PMID: 21790605
DOI: 10.1111/j.1471-4159.2011.07399.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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