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Article

KIAA1549: BRAF Gene Fusion and FGFR1 Hotspot Mutations Are Prognostic Factors in Pilocytic Astrocytomas.

Journal of neuropathology and experimental neurology - 1 Jul 2015

Becker Aline Paixão, Scapulatempo-Neto Cristovam, Carloni Adriana C, Paulino Alessandra, Sheren Jamie, Aisner Dara L, Musselwhite Evelyn, Clara Carlos, Machado Hélio R, Oliveira Ricardo S, Neder Luciano, Varella-Garcia Marileila, Reis Rui M

Abstract excerpt

Up to 20% of patients with pilocytic astrocytoma (PA) experience a poor outcome. BRAF alterations and Fibroblast growth factor receptor 1 (FGFR1) point mutations are key molecular alterations in Pas, but their clinical implications are not established. We aimed to determine the frequency and prognostic role of these alterations in a cohort of 69 patients with PAs. We assessed KIAA1549:BRAF fusion by fluorescence...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 26083571
DOI: 10.1097/NEN.0000000000000213
PMCID: PMC4470527

Genes

BRAF
FGFR1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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