MAPK pathway activation through <i>BRAF</i> gene fusion in pilocytic astrocytomas; a novel oncogenic fusion gene with diagnostic, prognostic, and therapeutic potential

Abstract excerpt

Abstract Recently, a new mechanism for activation of B‐RAF was identified resulting from a tandem duplication, generating a fusion protein with constitutive BRAF activity and thereby activating the MAPK pathway. Different fusion variants involving BRAF and KIAA1549 were demonstrated, present in 80% of pilocytic astrocytomas in children. As the KIAA1549–BRAF fusion gene is detected at a much lower frequency in...

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