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Article

A new NFIA:RAF1 fusion activating the MAPK pathway in pilocytic astrocytoma.

Cancer genetics - 1 Oct 2016

Yde Christina Westmose, Sehested Astrid, Mateu-Regué Àngels, Østrup Olga, Scheie David, Nysom Karsten, Nielsen Finn Cilius, Rossing Maria

Abstract excerpt

Pilocytic astrocytoma (PA) is one of the most common brain cancers among children and activation of the Mitogen-Activated Protein Kinase (MAPK) pathway is considered the hallmark. In the majority of cases, oncogenic BRAF fusions or BRAF V600E mutations are observed, while RAF1 or NF1 alterations are more rarely found. However, in some cases, no apparent cancer driver events can be identified. Here, we describe a...

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Identifiers

PMID: 27810072
DOI: 10.1016/j.cancergen.2016.09.002

Genes

RAF1
NFIA
BRAF

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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