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Article

Influence of polymorphisms in anthracyclines metabolism genes in the standard induction chemotherapy of acute myeloid leukemia.

Pharmacogenetics and genomics - 1 Aug 2021

Megías-Vericat Juan Eduardo, Martínez-Cuadrón David, Herrero María José, Rodríguez-Veiga Rebeca, Solana-Altabella Antonio, Boluda Blanca, Ballesta-López Octavio, Cano Isabel, Acuña-Cruz Evelyn, Cervera José, Poveda José Luis, Sanz Miguel Ángel, Aliño Salvador F, Montesinos Pau

Abstract excerpt

OBJECTIVES: Genetic variability in anthracycline metabolism could modify the response and safety of acute myeloid leukemia (AML) induction. METHODS: Polymorphisms in genes that encodes enzymes of anthracyclines metabolic pathway (CBR3: rs1056892, rs8133052, NQO1: rs1800566, NQO2: rs1143684, NOS3: rs1799983, ) were evaluated in 225 adult de novo AML patients. RESULTS: The variant CBR3 was...

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PMID: 33675324
DOI: 10.1097/FPC.0000000000000431

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