Polygenic Ara-C Response Score Identifies Pediatric Patients With Acute Myeloid Leukemia in Need of Chemotherapy Augmentation.

doi:10.1200/JCO.21.01422

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Article

Polygenic Ara-C Response Score Identifies Pediatric Patients With Acute Myeloid Leukemia in Need of Chemotherapy Augmentation.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Mar 2022

Elsayed Abdelrahman H, Cao Xueyuan, Mitra Amit K, Wu Huiyun, Raimondi Susana, Cogle Christopher, Al-Mansour Zeina, Ribeiro Raul C, Gamis Alan, Kolb Edward Anders, Aplenc Richard, Alonzo Todd A, Meshinchi Soheil, Rubnitz Jeffrey, Pounds Stanley, Lamba Jatinder K

Abstract excerpt

PURPOSE: To establish a patient-specific polygenic score derived from cytarabine (ara-C) pathway pharmacogenomic evaluation to personalize acute myeloid leukemia (AML) treatment. MATERIALS AND METHODS: Single nucleotide polymorphisms (SNPs) in the ara-C-pathway genes were analyzed with outcome in patients from the multicenter-AML02 trial (N = 166). Multi-SNP predictor modeling was used to develop 10-SNP Ara-C_SNP...

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PMID: 34990262
DOI: 10.1200/JCO.21.01422
PMCID: PMC8887949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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