Article
Bidirectional alteration of Cav-1 expression is associated with mitogenic conversion of its function in gastric tumor progression.
BMC cancer - 15 Nov 2017
Ryu Byung-Kyu, Lee Min-Goo, Kim Nam-Hoon, Lee Kil Yeon, Oh Shin-Ju, Moon Jung-Rock, Kim Hyo Jong, Chi Sung-Gil
Abstract excerpt
BACKGROUND: Expression of caveolin-1 (Cav-1) is frequently altered in many human cancers and both tumor suppression and promotion functions of Cav-1 have been suggested based on its expression status. However, it remains unanswered how Cav-1 provokes opposite effects in different cancers or different phases of tumor progression. METHODS: To explore the implication of Cav-1 alteration in gastric tumorigenesis, the...
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