Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SKI and MEL1 Cooperate to Inhibit Transforming Growth Factor-β Signal in Gastric Cancer Cells

3 Dec 2008

Abstract excerpt

Chromosomal amplification occurs frequently in solid tumors and is associated with poor prognosis. Several reports demonstrated the cooperative effects of oncogenic factors in the same amplicon during cancer development. However, the functional correlation between the factors remains unclear. Transforming growth factor (TGF)-beta signaling plays important roles in cytostasis and normal epithelium differentiation,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to FOXO transcription factor regulation
Share to Pancreatic and Hepatic Oncology Research
Share to Pediatric Hepatobiliary Diseases and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19049980
DOI: 10.1074/jbc.m808989200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SKI and MEL1 Cooperate to Inhibit Transforming Growth Factor-β Signal in Gastric Cancer CellsPMID 19049980Read ↗

Repression of TGF-β signaling by the oncogenic protein SKI in human melanomas: consequences for proliferation, survival, and metastasisSemantic proximity Read ↗

Comprehensive Analysis of SMARCB1 and SMARCA4 Expression Profiles and Their Clinical Correlations in Gastric CancerSemantic proximity Read ↗

Interaction of the Ski Oncoprotein with Smad3 Regulates TGF-β SignalingSemantic proximity Read ↗

Ski and SnoN: negative regulators of TGF-β signalingSemantic proximity Read ↗

The Oncoprotein Ski Acts as an Antagonist of Transforming Growth Factor-β Signaling by Suppressing Smad2 PhosphorylationSemantic proximity Read ↗

Bidirectional alteration of Cav-1 expression is associated with mitogenic conversion of its function in gastric tumor progression.Semantic proximity Read ↗

SMC1A facilitates gastric cancer cells proliferation, migration and invasion via promoting SNAI2 activated EMTSemantic proximity Read ↗

The oncoprotein Evi-1 represses TGF-β signalling by inhibiting Smad3Semantic proximity Read ↗

miR-577 Regulates TGF-β Induced Cancer Progression through a SDPR-Modulated Positive-Feedback Loop with ERK-NF-κB in Gastric CancerSemantic proximity Read ↗

MYC interaction with the tumor suppressive SWI/SNF complex member INI1 regulates transcription and cellular transformationSemantic proximity Read ↗

SMC1A facilitates gastric cancer cells proliferation, migration and invasion via promoting SNAIL activated EMTSemantic proximity Read ↗

SCL/TAL1 Interrupting Locus Derepresses GLI1 from the Negative Control of Suppressor-of-Fused in Pancreatic Cancer CellSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.