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MBP-1 Suppresses Growth and Metastasis of Gastric Cancer Cells through COX-2

22 Oct 2009

Abstract excerpt

The c-Myc promoter binding protein 1 (MBP-1) is a transcriptional suppressor of c-myc expression and involved in control of tumorigenesis. Gastric cancer is one of the most frequent neoplasms and lethal malignancies worldwide. So far, the regulatory mechanism of its aggressiveness has not been clearly characterized. Here we studied roles of MBP-1 in gastric cancer progression. We found that cell proliferation was...

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PMID: 19846662
DOI: 10.1091/mbc.e09-05-0386

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