Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Caveolin-1 Confers Resistance of Hepatoma Cells to Anoikis by Activating IGF-1 Pathway.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2015

Tang Wenqing, Feng Xuemei, Zhang Si, Ren Zhenggang, Liu Yinkun, Yang Biwei, lv Bei, Cai Yu, Xia Jinglin, Ge Ningling

Abstract excerpt

BACKGROUND/AIMS: Anoikis resistance is a prerequisite for hepatocellular carcinoma (HCC) metastasis. The role of Caveolin-1 (CAV1) in anoikis resistance of HCC remains unclear. METHODS: The oncogenic effect of CAV1 on anchor-independent growth and anoikis resistance was investigated by overexpression and knockdown of CAV1 in hepatoma cells. IGF-1 pathway and its downstream signals were detected by immunoblot...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caveolin 1
Share to Caveolae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Signal-Regulated MAP Kinases

Share to Insulin-Like Growth Factor I

Share to MAP Kinase Kinase Kinases

Share to Proto-Oncogene Proteins c-akt

Share to raf Kinases

Share to Receptor, IGF Type 1

Source

Identifiers

PMID: 26138883
DOI: 10.1159/000430292

Genes

CAV1
IGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Caveolin-1 Confers Resistance of Hepatoma Cells to Anoikis by Activating IGF-1 Pathway.PMID 26138883Read ↗

Acquisition of anoikis resistance up-regulates caveolin-1 expression in human non-small cell lung cancer cells.Semantic proximity Read ↗

Caveolin-1 is up-regulated by GLI1 and contributes to GLI1-driven EMT in hepatocellular carcinoma.Semantic proximity Read ↗

Inhibition of the Caveolin-1 pathway promotes apoptosis and overcomes pan-tyrosine kinase inhibitor resistance in hepatocellular carcinomaSemantic proximity Read ↗

IGF-IR internalizes with Caveolin-1 and PTRF/Cavin in HaCat cells.Semantic proximity Read ↗

Reciprocal Activating Crosstalk between c-Met and Caveolin 1 Promotes Invasive Phenotype in Hepatocellular CarcinomaSemantic proximity Read ↗

Bidirectional alteration of Cav-1 expression is associated with mitogenic conversion of its function in gastric tumor progression.Semantic proximity Read ↗

Caveolin‐1 is an Important Factor for the Metastasis and Proliferation of Human Small Cell Lung Cancer NCI‐H446 CellSemantic proximity Read ↗

ABCA1 overexpression worsens colorectal cancer prognosis by facilitating tumour growth and caveolin-1-dependent invasiveness, and these effects can be ameliorated using the BET inhibitor apabetalone.Semantic proximity Read ↗

Caveolin 1 expression correlates with poor prognosis and focal adhesion kinase expression in gastric cancer.Semantic proximity Read ↗

Caveolin-1 in Cell Migration and MetastasisSemantic proximity Read ↗

The influence of a caveolin-1 mutant on the function of P-glycoprotein.Semantic proximity Read ↗

Claudin-1 expression confers resistance to anoikis in colon cancer cells in a Src-dependent mannerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.