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Article

PTBP3 contributes to the metastasis of gastric cancer by mediating CAV1 alternative splicing

11 May 2018

Abstract excerpt

Polypyrimidine tract-binding protein 3 (PTBP3) is an essential RNA-binding protein with roles in RNA splicing, 3' end processing and translation. Although increasing evidence implicates PTBP3 in several cancers, its role in gastric cancer metastasis remains poorly explored. In this study, we found that PTBP3 was upregulated in the gastric cancer tissues of patients with lymph node metastasis. Patients with high...

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PMID: 29752441
DOI: 10.1038/s41419-018-0608-8

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