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Article

Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer.

Nature genetics - 1 May 2014

Nik-Zainal Serena, Wedge David C, Alexandrov Ludmil B, Petljak Mia, Butler Adam P, Bolli Niccolo, Davies Helen R, Knappskog Stian, Martin Sancha, Papaemmanuil Elli, Ramakrishna Manasa, Shlien Adam, Simonic Ingrid, Xue Yali, Tyler-Smith Chris, Campbell Peter J, Stratton Michael R

Abstract excerpt

The somatic mutations in a cancer genome are the aggregate outcome of one or more mutational processes operative through the lifetime of the individual with cancer. Each mutational process leaves a characteristic mutational signature determined by the mechanisms of DNA damage and repair that cons...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24728294
DOI: 10.1038/ng.2955
PMCID: PMC4137149

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24728294-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer.PMID 24728294Read ↗

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Signatures of mutational processes in human cancer.Semantic proximity Read ↗

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The topography of mutational processes in breast cancer genomes.Semantic proximity Read ↗

APOBEC in breast cancer: a dual player in tumor evolution and therapeutic responseSemantic proximity Read ↗

Mutational processes molding the genomes of 21 breast cancers.Semantic proximity Read ↗

APOBEC3B, a molecular driver of mutagenesis in human cancersSemantic proximity Read ↗

Integrative genomic analyses of APOBEC-mutational signature, expression and germline deletion of APOBEC3 genes, and immunogenicity in multiple cancer typesSemantic proximity Read ↗

Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancerSemantic proximity Read ↗

APOBEC3A is a prominent cytidine deaminase in breast cancer.Semantic proximity Read ↗

Germline variants and somatic mutation signatures of breast cancer across populations of African and European ancestry in the US and NigeriaSemantic proximity Read ↗

APOBEC3 mutational signatures are associated with extensive and diverse genomic instability across multiple tumour types.Semantic proximity Read ↗

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