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Internal Affairs: Tenascin-C as a Clinically Relevant, Endogenous Driver of Innate Immunity

31 Jan 2018

Abstract excerpt

To protect against danger, the innate immune system must promptly and accurately sense alarm signals, and mount an appropriate response to restore homeostasis. One endogenous trigger of immunity is tenascin-C, a large hexameric protein of the extracellular matrix. Upregulated upon tissue injury and cellular stress, tenascin-C is expressed during inflammation and tissue remodeling, where it influences cellular...

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PMID: 29385356
DOI: 10.1369/0022155418757443

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