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Article

What Is Resistance? Impact of Phenotypic versus Molecular Drug Resistance Testing on Therapy for Multi- and Extensively Drug-Resistant Tuberculosis.

Antimicrobial agents and chemotherapy - 1 Feb 2018

Heyckendorf Jan, Andres Sönke, Köser Claudio U, Olaru Ioana D, Schön Thomas, Sturegård Erik, Beckert Patrick, Schleusener Viola, Kohl Thomas A, Hillemann Doris, Moradigaravand Danesh, Parkhill Julian, Peacock Sharon J, Niemann Stefan, Lange Christoph, Merker Matthias

Abstract excerpt

Rapid and accurate drug susceptibility testing (DST) is essential for the treatment of multi- and extensively drug-resistant tuberculosis (M/XDR-TB). We compared the utility of genotypic DST assays with phenotypic DST (pDST) using Bactec 960 MGIT or Löwenstein-Jensen to construct M/XDR-TB treatment regimens for a cohort of 25 consecutive M/XDR-TB patients and 15 possible anti-TB drugs. Genotypic DST results from...

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Identifiers

PMID: 29133554
DOI: 10.1128/AAC.01550-17
PMCID: PMC5786814

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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