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Article

Deep Amplicon Sequencing Reveals Culture-dependent Clonal Selection of Mycobacterium tuberculosis in Clinical Samples.

Genomics, proteomics & bioinformatics - 15 Jan 2025

Qu Jiuxin, Liu Wanfei, Chen Shuyan, Wu Chi, Lai Wenjie, Qin Rui, Ye Feidi, Li Yuanchun, Fu Liang, Deng Guofang, Liu Lei, Lin Qiang, Cui Peng

Abstract excerpt

The commonly-used drug susceptibility testing (DST) relies on bacterial culture and faces shortcomings such as long turnaround time and clonal/subclonal selection biases. Here, we developed a targeted deep amplicon sequencing (DAS) method directly applied to clinical specimens. In this DAS panel, we examined 941 drug-resistant mutations (DRMs) associated with 20 anti-tuberculosis drugs with only 4 pg of initial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38870522
DOI: 10.1093/gpbjnl/qzae046
PMCID: PMC11978391

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DST

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