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Single Cell Immuno-Laser Microdissection Coupled to Label-Free Proteomics to Reveal the Proteotypes of Human Brain Cells After Ischemia.

Molecular & cellular proteomics : MCP - 1 Jan 2018

García-Berrocoso Teresa, Llombart Víctor, Colàs-Campàs Laura, Hainard Alexandre, Licker Virginie, Penalba Anna, Ramiro Laura, Simats Alba, Bustamante Alejandro, Martínez-Saez Elena, Canals Francesc, Sanchez Jean-Charles, Montaner Joan

Abstract excerpt

Cerebral ischemia entails rapid tissue damage in the affected brain area causing devastating neurological dysfunction. How each component of the neurovascular unit contributes or responds to the ischemic insult in the context of the human brain has not been solved yet. Thus, the analysis of the proteome is a straightforward approach to unraveling these cell proteotypes. In this study, post-mortem brain slices...

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Identifiers

PMID: 29133510
DOI: 10.1074/mcp.RA117.000419
PMCID: PMC5750846

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SRSF1

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