Single-cell sequencing-based study of ferroptosis mechanisms in heat stroke: identification of key biomarkers and dynamic analysis of the immune microenvironment

Abstract excerpt

BACKGROUND: Heat stroke, caused by excessive heat production or impaired dissipation, often results from prolonged heat exposure or strenuous activity. Ferroptosis, a novel form of programmed cell death, has been implicated in its pathogenesis, though its mechanisms remain unclear. OBJECTIVE: This study investigates the molecular mechanisms linking heat stroke and ferroptosis using single-cell and transcriptomic...

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