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Detection of SNPs of T2DM susceptibility genes by a ligase detection reaction-fluorescent nanosphere technique.

Analytical biochemistry - 1 Jan 2018

Chen Yan, Zhao Ying, Li Yan-Bo, Wang Yan-Jun, Zhang Gui-Zhen

Abstract excerpt

OBJECTIVE: To establish a high throughput, low cost, and simple nanotechnology-based method for the detection of single nucleotide polymorphism (SNP) loci in type 2 diabetes mellitus (T2DM). METHODS: Multiplex ligase detection reaction (LDR) amplification was performed using fluorescently labeled magnetic nanosphere-bound upstream LDR probes and downstream probes labeled with a unique fluorescent group for each...

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PMID: 29128291
DOI: 10.1016/j.ab.2017.11.003

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