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Article

CG dinucleotide suppression enables antiviral defence targeting non-self RNA.

Nature - 5 Oct 2017

Takata Matthew A, Gonçalves-Carneiro Daniel, Zang Trinity M, Soll Steven J, York Ashley, Blanco-Melo Daniel, Bieniasz Paul D

Abstract excerpt

Vertebrate genomes exhibit marked CG suppression-that is, lower than expected numbers of 5'-CG-3' dinucleotides. This feature is likely to be due to C-to-T mutations that have accumulated over hundreds of millions of years, driven by CG-specific DNA methyl transferases and spontaneous methyl-cytosine deamination. Many RNA viruses of vertebrates that are not substrates for DNA methyl transferases mimic the CG...

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Identifiers

PMID: 28953888
DOI: 10.1038/nature24039
PMCID: PMC6592701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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