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Source of CpG Depletion in the HIV-1 Genome

28 Sept 2016

Abstract excerpt

The dinucleotide CpG is highly underrepresented in the genome of human immunodeficiency virus type 1 (HIV-1). To identify the source of CpG depletion in the HIV-1 genome, we investigated two biological mechanisms: (1) CpG methylation-induced transcriptional silencing and (2) CpG recognition by Toll-like receptors (TLRs). We hypothesized that HIV-1 has been under selective evolutionary pressure by these mechanisms...

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PMID: 27682824
DOI: 10.1093/molbev/msw205

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