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Article

Colorectal cancer susceptibility loci as predictive markers of rectal cancer prognosis after surgery.

Genes, chromosomes & cancer - 1 Mar 2018

Hu Yue, Gaedcke Jochen, Emons Georg, Beissbarth Tim, Grade Marian, Jo Peter, Yeager Meredith, Chanock Stephen J, Wolff Hendrik, Camps Jordi, Ghadimi B Michael, Ried Thomas

Abstract excerpt

To understand the molecular mechanism of rectal cancer and develop markers for disease prognostication, we generated and explored a dataset from 243 rectal cancer patients by gene expression microarray analysis of cancer samples and matched controls, and SNP-arrays of germline DNA. We found that two of the loci most strongly linked with colorectal cancer (CRC) risk, 8q24 (upstream of MYC) and 18q21 (in the intron...

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Identifiers

PMID: 29119627
DOI: 10.1002/gcc.22512
PMCID: PMC5778444

Genes

MYC
SMAD7
LAMA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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