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Article

Structural basis for alpha1 versus alpha2 isoform-distinct behavior of the Na,K-ATPase.

The Journal of biological chemistry - 14 Mar 2003

Segall Laura, Javaid Zahid Z, Carl Stephanie L, Lane Lois K, Blostein Rhoda

Abstract excerpt

We showed earlier that the kinetic behavior of the alpha2 isoform of the Na,K-ATPase differs from the ubiquitous alpha1 isoform primarily by a shift in the steady-state E(1)/E(2) equilibrium of alpha2 in favor of E(1) form(s). The aim of the present study was to identify regions of the alpha chain that confer the alpha1/alpha2 distinct behavior using a mutagenesis and chimera approach. Criteria to assess shifts...

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PMID: 12529322
DOI: 10.1074/jbc.M211636200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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