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Article

Intracellular localization of Na,K-ATPase alpha2 subunit mutants.

Archives of biochemistry and biophysics - 15 Oct 1997

Coppi M V, Guidotti G

Abstract excerpt

The Na,K-ATPase is an essential plasma membrane transporter of mammalian cells composed of two subunits, alpha and beta, of which there are several isoforms. We investigated the effect of a substitution, S364P, on the subcellular localization and enzymatic activity of the wild-type alpha2 and alpha2L111R,N122D (alpha2RD) subunits. The substitutions, L111R and N122D, lower the affinity of the alpha2 subunit for...

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PMID: 9343379
DOI: 10.1006/abbi.1997.0332

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