Article
SNPs in Aβ clearance proteins: Lower CSF Aβ1-42 levels and earlier onset of dementia in PD.
Neurology - 5 Dec 2017
Brockmann Kathrin, Lerche Stefanie, Dilger Sarah Selina, Stirnkorb Johannes Georg, Apel Anja, Hauser Ann-Kathrin, Liepelt-Scarfone Inga, Berg Daniela, Gasser Thomas, Schulte Claudia, Maetzler Walter
Abstract excerpt
OBJECTIVE: To evaluate whether genetic variants in β-amyloid (Aβ) clearance proteins are associated with CSF levels of Aβ1-42 on a biological level and the onset of dementia on a clinical level in Parkinson disease (PD). METHODS: We analyzed genetic variants known to be involved in Aβ clearance in a PD group comprising 456 patients, 103 of them with dementia. Single nucleotide polymorphisms in the genes APOE,...
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