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Article

Characterization of Nucleoside Reverse Transcriptase Inhibitor-Associated Mutations in the RNase H Region of HIV-1 Subtype C Infected Individuals.

Viruses - 8 Nov 2017

Ngcapu Sinaye, Theys Kristof, Libin Pieter, Marconi Vincent C, Sunpath Henry, Ndung'u Thumbi, Gordon Michelle L

Abstract excerpt

The South African national treatment programme includes nucleoside reverse transcriptase inhibitors (NRTIs) in both first and second line highly active antiretroviral therapy regimens. Mutations in the RNase H domain have been associated with resistance to NRTIs but primarily in HIV-1 subtype B studies. Here, we investigated the prevalence and association of RNase H mutations with NRTI resistance in sequences...

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Identifiers

PMID: 29117130
DOI: 10.3390/v9110330
PMCID: PMC5707537

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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