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Article

Effects of mutations in the connection and RNase H domains of HIV-1 reverse transcriptase on drug susceptibility.

AIDS reviews - 1 Jan 2000

Ehteshami Maryam, Götte Matthias

Abstract excerpt

Despite the success in the development of antiretroviral therapy, the emergence of drug resistance remains an important factor that can undermine the benefits of treatment. The vast majority of well-described resistance-associated mutations are clustered around the binding site for a given inhibitor. However, mutations that are observed at considerable distance from this location can likewise affect drug...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 19092978

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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