Article
Conservation patterns of HIV-1 RT connection and RNase H domains: identification of new mutations in NRTI-treated patients.
PloS one - 12 Mar 2008
Santos André F A, Lengruber Renan B, Soares Esmeralda A, Jere Abhay, Sprinz Eduardo, Martinez Ana M B, Silveira Jussara, Sion Fernando S, Pathak Vinay K, Soares Marcelo A
Abstract excerpt
BACKGROUND: Although extensive HIV drug resistance information is available for the first 400 amino acids of its reverse transcriptase, the impact of antiretroviral treatment in C-terminal domains of Pol (thumb, connection and RNase H) is poorly understood. METHODS AND FINDINGS: We wanted to characterize conserved regions in RT C-terminal domains among HIV-1 group M subtypes and CRF. Additionally, we wished to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.