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Article

Wnt/β‑catenin pathway activation and silencing of the APC gene in HPV‑positive human cervical cancer‑derived cells.

Molecular medicine reports - 1 Jan 2018

Ayala-Calvillo Erick, Mojica-Vázquez Luis Humberto, García-Carrancá Alejandro, González-Maya Leticia

Abstract excerpt

Although persistent infections with high‑risk human papilloma virus (HPV) constitute the most significant cofactor for the development of cervical cancer, they are insufficient on their own. Mutations or epigenetic inactivation of the tumor suppressor adenomatous polyposis coli (APC), the two acting as prominent oncogenic mechanisms in a number of types of cancer, are frequently associated with aberrant...

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Identifiers

PMID: 29115417
DOI: 10.3892/mmr.2017.7853
PMCID: PMC5780127

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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