Article
Alterations and correlations of the components in the Wnt signaling pathway and its target genes in breast cancer.
Oncology reports - 1 Dec 2005
Ozaki Shinji, Ikeda Satoshi, Ishizaki Yasuyo, Kurihara Takeshi, Tokumoto Noriaki, Iseki Masahiko, Arihiro Koji, Kataoka Tsuyoshi, Okajima Mazazumi, Asahara Toshimasa
Abstract excerpt
Both cyclin D1 and c-myc are key molecules in breast cancer carcinogenesis, and their transcriptional level and stability are regulated through several signaling pathways, including the Wnt signaling pathway. We performed immunohistochemical and mutational analyses of Wnt signaling components to investigate the association of Wnt signaling alterations with breast cancer carcinogenesis using 49 surgically resected...
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