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Article

SORLA attenuates EphA4 signaling and amyloid β-induced neurodegeneration.

The Journal of experimental medicine - 4 Dec 2017

Huang Timothy Y, Zhao Yingjun, Jiang Lu-Lin, Li Xiaoguang, Liu Yan, Sun Yu, Piña-Crespo Juan C, Zhu Bing, Masliah Eliezer, Willnow Thomas E, Pasquale Elena B, Xu Huaxi

Abstract excerpt

Sortilin-related receptor with LDLR class A repeats (SORLA, SORL1, or LR11) is a genetic risk factor associated with Alzheimer's disease (AD). Although SORLA is known to regulate trafficking of the amyloid β (Aβ) precursor protein to decrease levels of proteotoxic Aβ oligomers, whether SORLA can counteract synaptic dysfunction induced by Aβ oligomers remains unclear. Here, we show that SORLA interacts with the...

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Share to Amyloid beta-Protein Precursor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29114064
DOI: 10.1084/jem.20171413
PMCID: PMC5716044

Genes

LDLR
SORL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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