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Article

Assessing positive and negative valence systems to refine animal models of bipolar disorders: the example of GBR 12909-induced manic phenotype.

Scientific reports - 5 May 2022

Bigot Mathilde, Vicq Eleonore, Lledo Pierre-Marie, Alonso Mariana, Henry Chantal

Abstract excerpt

Bipolar disorders are defined by recurrences of depressive and manic episodes. The pathophysiology is still unknown, and translating clinical symptoms into behaviors explorable in animal models is challenging. Animal models of bipolar disorder do not exist because cyclicity of the disease is impossible to mimic, and it is therefore necessary to study mania and depression models separately. Beyond mood, emotional...

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PMID: 35513683
DOI: 10.1038/s41598-022-10965-8
PMCID: PMC9072677

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