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Article

Genome-wide genetic and epigenetic analyses of pancreatic acinar cell carcinomas reveal aberrations in genome stability.

Nature communications - 6 Nov 2017

Jäkel Cornelia, Bergmann Frank, Toth Reka, Assenov Yassen, van der Duin Daniel, Strobel Oliver, Hank Thomas, Klöppel Günter, Dorrell Craig, Grompe Markus, Moss Joshua, Dor Yuval, Schirmacher Peter, Plass Christoph, Popanda Odilia, Schmezer Peter

Abstract excerpt

Pancreatic acinar cell carcinoma (ACC) is an aggressive exocrine tumor with largely unknown biology. Here, to identify potential targets for personalized treatment, we perform integrative genome-wide and epigenome-wide analyses. The results show frequently aberrant DNA methylation, abundant chromosomal amplifications and deletions, and mutational signatures suggesting defective DNA repair. In contrast to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29109526
DOI: 10.1038/s41467-017-01118-x
PMCID: PMC5673892

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